法莫替丁对神经肌肉传递的影响。
The effect of famotidine on neuromuscular transmission.
作者信息
Bossa R, Chiericozzi M, Efstathiu G, Galatulas I, Ninci M A
机构信息
Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica Emilio Trabucchi, Università di Milano, Italy.
出版信息
In Vivo. 1991 Jan-Feb;5(1):53-5.
We have investigated the effects of the H2 receptor antagonist famotidine on the neuromuscular transmission by using the sciatic nerve--gastrocnemius muscle preparation of rat in vitro. Famotidine, administered by I.V. injection, potentiates the neuromuscular blockade induced by d-tubocurarine, pancuronium and aminoglycoside antibiotics. Moreover, the drug alone is capable of producing a blockade on the preparation stimulated at high frequency. The neuromuscular blockade induced by famotidine is reversed by 4-aminopyridine but not by dimaprit. Similar results have previously been obtained with cimetidine.
我们利用大鼠坐骨神经-腓肠肌离体标本，研究了H2受体拮抗剂法莫替丁对神经肌肉传递的影响。通过静脉注射给予法莫替丁，可增强由d-筒箭毒碱、泮库溴铵和氨基糖苷类抗生素所诱导的神经肌肉阻滞。此外，该药物单独使用时，能够对高频刺激的标本产生阻滞作用。法莫替丁所诱导的神经肌肉阻滞可被4-氨基吡啶逆转，但不能被二甲双胍逆转。西咪替丁此前也得到了类似的结果。
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