血清素在中脑导水管周围灰质（PAG）中由吗啡引发的镇痛作用中的角色。
The role of serotonin in analgesia elicited by morphine in the periaqueductal gray matter (PAG).
作者信息
Schul R, Frenk H
机构信息
Department of Psychology, Tel Aviv University, Ramat Aviv, Israel.
出版信息
Brain Res. 1991 Jul 12;553(2):353-7. doi: 10.1016/0006-8993(91)90849-q.
PMID:1681985
Abstract
The serotonergic antagonist, methysergide, administered into the periaqueductal gray matter (PAG), inhibited the antinociceptive effect of morphine, but not of glutamate, also administered into the PAG. At this dose methysergide did not alter the pain threshold when administered by itself. The implications for serotonin's role in the modulation of nociception in the PAG are discussed.
摘要
将5-羟色胺能拮抗剂麦角酸二乙胺注入中脑导水管周围灰质（PAG），可抑制吗啡的镇痛作用，但对同样注入PAG的谷氨酸的镇痛作用无影响。在此剂量下，麦角酸二乙胺单独给药时不会改变痛阈。本文讨论了5-羟色胺在PAG伤害感受调制中的作用。
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