Schulze U, Wohlke A, Drogemoller C, Marxfeld H, De Vries F, Baumgartner W, Distl O
Institut für Tierzucht und Vererbungsforschung, Stiftung Tierärztliche Hochschule Hannover.
Dtsch Tierarztl Wochenschr. 2006 May;113(5):203-6.
A female German Holstein calf was not able to stand up after birth. Resting the animal was lying in normal position and could lift its head. Sensory stimuli like auditory or tactile impulses induced myoclonic jerking of the whole body. Afterwards it calmed down quickly. The signs observed correspond to the clinical findings of congenital myoclonus in poll Hereford calves. The pathological examination revealed no indications for changes in organs. The inbreeding coefficient of the calf was 1.56 %. The present type of congenital myoclonus in the calf examined is likely to be genetically determined, even if the point mutation in exon 2 of the glycin receptor alpha 1 gene was not confirmed.
一头德国荷斯坦小母牛出生后无法站立。动物休息时处于正常姿势,能够抬起头部。听觉或触觉等感觉刺激会引发全身肌阵挛性抽搐。之后它很快就平静下来。观察到的症状与波耳赫里福德小牛先天性肌阵挛的临床症状相符。病理检查未发现器官有变化的迹象。这头小牛的近亲繁殖系数为1.56%。即使未证实甘氨酸受体α1基因外显子2中的点突变,所检查小牛目前这种先天性肌阵挛类型很可能是由基因决定的。