Hammerschmidt S
Zentrum für Innere Medizin, Pneumologie, Universität Leipzig.
MMW Fortschr Med. 2006 Jun 1;148(22):28, 30-1.
Screening studies involving chest x-rays with and without additional sputum cytology, have failed to bring about any reduction in mortality from lung cancer. With regard to all other potential screening methods, no studies investigating tumor-specific mortality are available. Against such a background, none of the relevant societies recommend systematic screening. Sputum cytology is sensitive only for central lesions. Autofluorescence bronchoscopy is limited to the detection of early malignant and premalignant lesions in the central airways. While CT screening detects numerous round foci, only a few of these prove to be carcinomas. In contrast to these findings, we have the positive results of non-controlled screening studies employing low-dose CT, which, however, has not been widely accepted.
涉及胸部X光检查（无论是否附加痰细胞学检查）的筛查研究未能降低肺癌死亡率。对于所有其他潜在的筛查方法，尚无关于肿瘤特异性死亡率的研究。在此背景下，相关协会均不推荐进行系统性筛查。痰细胞学检查仅对中央型病变敏感。自发荧光支气管镜检查仅限于检测中央气道的早期恶性和癌前病变。虽然CT筛查能检测到众多圆形病灶，但其中只有少数被证实为癌。与这些结果形成对比的是，我们有采用低剂量CT的非对照筛查研究的阳性结果，然而，低剂量CT尚未被广泛接受。
