在口腔鳞状细胞癌中，Mcm-2蛋白表达比Ki-67抗原更能预测预后。
Mcm-2 protein expression predicts prognosis better than Ki-67 antigen in oral cavity squamocellular carcinoma.
作者信息
Szelachowska Jolanta, Dziegiel Piotr, Jelen-Krzeszewska Joanna, Jelen Michal, Matkowski Rafal, Pomiecko Agnieszka, Spytkowska Barbara, Jagas Maria, Gisterek Iwona, Kornafel Jan
机构信息
Department of Oncology, Wroclaw Medical University, Plac Hirszfelda 12, 53-413 Wroclaw, Poland.
出版信息
Anticancer Res. 2006 May-Jun;26(3B):2473-8.
BACKGROUND
The present study aimed at evaluating the expression intensities of the Mcm-2 protein and Ki-67 antigen in squamocellular carcinomas of the oral cavity and comparing their prognostic value.
MATERIALS AND METHODS
Forty-nine patients, operated on and treated with radiotherapy for carcinoma of the oral cavity floor and/or the mobile part of the tongue, were retrospectively analyzed.
RESULTS
A significant positive correlation was noted between the expression of Mcm-2 protein and that of the Ki-67 antigen, as well as an absence of such correlations with the remaining examined factors. A significant correlation with worse disease-specific survival period (DSS) in the group of patients demonstrating Mcm-2 protein expression in over 10% of cancer cells was detected (5-year cumulative DSS 50% vs. 76%).
CONCLUSION
The results suggested that the expression of Mcm-2 protein may be used as a prognostic factor in patients with squamocellular carcinoma of the oral cavity.
背景
本研究旨在评估口腔鳞状细胞癌中Mcm-2蛋白和Ki-67抗原的表达强度，并比较它们的预后价值。
材料与方法
对49例因口腔底部和/或舌活动部癌接受手术及放疗的患者进行回顾性分析。
结果
Mcm-2蛋白表达与Ki-67抗原表达之间存在显著正相关，且与其余检测因素无此类相关性。在癌细胞中Mcm-2蛋白表达超过10%的患者组中，检测到与较差的疾病特异性生存期（DSS）存在显著相关性（5年累积DSS为50%对76%）。
结论
结果表明，Mcm-2蛋白的表达可作为口腔鳞状细胞癌患者的预后因素。
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