Eleftheriadou Anna, Chalastras Thomas, Ferekidou Elisa, Kyriou Lambrini, Yiotakis Ioannis, Pappas Zisis, Ferekidis Eleftherios, Kandiloros Dimitrios
Department of Otolaryngology, G. Gennimatas Hospital, Athens, Greece.
Anticancer Res. 2006 May-Jun;26(3B):2493-7.
The aim of this study was to examine and compare the value of the serum tumor markers CYFRA 21-1, TPA-M, SCCA and CEA in squamous cell carcinoma (SCC) of the larynx. Moreover, their possible clinical applications were studied.
The serum levels of CYFRA 21-1, TPA-M, SCCA and CEA were measured in 79 patients with histologically-proven squamous cell carcinoma (SCC) of the larynx before and after treatment and in 77 healthy volunteers. The association of the results with the clinicopathological characteristics was investigated.
The study showed that none of the markers revealed a significant sensitivity; TPA-M indicated a positive correlation with the grade of differentiation. CEA indicated a positive correlation only with distant metastasis.
Among the four markers, only TPA-M may play a role in monitoring the success of therapy and follow-up in patients with SCC of the larynx.
本研究旨在检测并比较血清肿瘤标志物细胞角蛋白19片段（CYFRA 21-1）、组织多肽抗原变异体M（TPA-M）、鳞状细胞癌抗原（SCCA）和癌胚抗原（CEA）在喉鳞状细胞癌（SCC）中的价值。此外，还研究了它们可能的临床应用。
检测79例经组织学证实的喉鳞状细胞癌患者治疗前后及77名健康志愿者血清中CYFRA 21-1、TPA-M、SCCA和CEA的水平。研究结果与临床病理特征的相关性。
研究表明，这些标志物均未显示出显著的敏感性；TPA-M与分化程度呈正相关。CEA仅与远处转移呈正相关。
在这四种标志物中，只有TPA-M可能在监测喉鳞状细胞癌患者的治疗效果和随访中发挥作用。
