Monteiro E, Varzim G, Crespo M, Araújo L
ORL Department, Portuguese Institute of Oncology, Porto, Portugal.
An Otorrinolaringol Ibero Am. 2003;30(5):467-79.
Serologic tumor markers are actually a valuable tool for diagnosis, management and follow up in some cancer types. The concentrations of Cyfra 21.1, SCC and TPS has been analysed in several groups of head and neck tumors, but exclusively in larynx there are no studies concerning this subject.
The purpose of the present study was to assess the expression of serum fragments of cytokeratins (CK's) 18/19, and squamous cell carcinoma antigen (SCCA) in a same group of patients with squamous cell carcinoma of larynx, and correlate the results with tumor localisation, T, stage, histology, presence of regional metastasis, and smoking habits.
Forty six patients treated at the Department of Otorhinolaryngology, Porto Center of the Portuguese Institute of Oncology were enrolled in the study. Blood samples were obtained before treatment, and determinations effectuated using standard commercial available kits.
Although serum concentrations of Cyfra 21.1, TPS and SCC were not significantly elevated in patients with laryngeal cancer, more expressive levels namely for TPS were observed in advanced supraglotic and metastasis tumors independent of the differentiation degree.
血清肿瘤标志物实际上是某些癌症类型诊断、治疗及随访的重要工具。已对多组头颈部肿瘤患者的细胞角蛋白片段21.1（Cyfra 21.1）、鳞状细胞癌抗原（SCC）和组织多肽特异性抗原（TPS）浓度进行了分析，但专门针对喉癌的相关研究尚无报道。
本研究旨在评估同一组喉鳞状细胞癌患者血清中细胞角蛋白（CK）18/19片段和鳞状细胞癌抗原（SCCA）的表达情况，并将结果与肿瘤定位、T分期、组织学、区域转移情况及吸烟习惯进行关联分析。
葡萄牙肿瘤研究所波尔图中心耳鼻喉科收治的46例患者纳入本研究。在治疗前采集血样，并使用标准商用试剂盒进行检测。
尽管喉癌患者血清中Cyfra 21.1、TPS和SCC浓度未显著升高，但在晚期声门上癌及转移癌患者中观察到TPS表达水平较高，且与分化程度无关。
