Thin-layer chromatography of sulphonamides on silica gel G and polyamide layers by means of a polar mobile phase.

A thin-layer chromatographic system based on polyamide or silica gel G layers and an aqueous mobile phase was used for the separation of a series of sulphonamides. A linear relationship between RM values on polyamide layers and the acetone concentration in the mobile phase allowed the calculation of extrapolated RM values. The influence of the nature of the stationary phase on the migration of compounds is discussed.