Savona-Ventura C, Grech E S, Saliba I
Department of Obstetrics & Gynaecology, St. Luke's Hospital, Malta.
Eur J Obstet Gynecol Reprod Biol. 1991 Oct 8;41(3):225-9. doi: 10.1016/0028-2243(91)90028-j.
One hundred patients undergoing vaginal surgery for genital prolapse were randomly allocated to one of four post-operative management groups which included a control group and three groups receiving differently acting pharmacological agents (distigmine bromide, phenoxybenzamine hydrochloride, and prostaglandin F2 alpha) variously reported as being useful in preventing urinary retention after vaginal surgery. The incidence of an elevated residual volume in the control group was 10.7%. All the pharmacological agents appeared to increase by about three times the incidence of an elevated residual urinary volume with statistical significance (P less than 0.05) being noted for distigmine bromide and PGF2 alpha. While this increased incidence occurred irrespective of the type of surgery in the case of distigmine bromide and phenoxybenzamine . HCl, the increase was most marked (P less than 0.01) when PGF2 alpha was used after anterior repair surgery.
一百名因生殖器脱垂接受阴道手术的患者被随机分配到四个术后管理组中的一组，其中包括一个对照组和三个接受不同作用药物治疗的组（溴化地斯的明、盐酸酚苄明和前列腺素F2α），这些药物均被报道对预防阴道手术后的尿潴留有用。对照组残余尿量增加的发生率为10.7%。所有药物似乎都使残余尿量增加的发生率提高了约三倍，溴化地斯的明和前列腺素F2α具有统计学意义（P<0.05）。虽然溴化地斯的明和盐酸酚苄明的这种发生率增加与手术类型无关，但在前壁修复手术后使用前列腺素F2α时，增加最为显著（P<0.01）。
