Lose G, Lindholm P
Int J Gynaecol Obstet. 1985 Sep;23(4):315-20. doi: 10.1016/0020-7292(85)90026-8.
To investigate the effect of prophylactic phenoxybenzamine on the bladder emptying after vaginal repair operations, 41 consecutive patients, who underwent the Manchester operation or an anterior + posterior repair because of genital descensus, were allocated at random to either prophylactic phenoxybenzamine (PBZ-group) or placebo treatment in the postoperative course. Prophylactic phenoxybenzamine was found to produce an improved emptying function of the bladder, leading to a statistically significant reduced number of acute urinary retentions (P = 0.029), decreased time until spontaneous voiding (P = 0.026) and reduced volume of residual urine (P = 0.018). Furthermore, a reduced incidence of urinary tract infections was found in the PBZ-group. Prophylactic phenoxybenzamine treatment is recommended as an alternative to routine bladder drainage in preventing urinary retention following vaginal repair operations for genital descensus.
为研究预防性使用酚苄明对阴道修复术后膀胱排空的影响，连续41例因生殖器脱垂接受曼彻斯特手术或前后壁修复术的患者，在术后随机分为预防性使用酚苄明组（PBZ组）或安慰剂治疗组。结果发现，预防性使用酚苄明可改善膀胱排空功能，使急性尿潴留的发生次数显著减少（P = 0.029），自主排尿时间缩短（P = 0.026），残余尿量减少（P = 0.018）。此外，PBZ组的尿路感染发生率降低。对于因生殖器脱垂行阴道修复术后预防尿潴留，推荐预防性使用酚苄明治疗作为常规膀胱引流的替代方法。
