Barlow Christopher K, Moran Damian, Radom Leo, McFadyen W David, O'Hair Richard A J
School of Chemistry, University of Melbourne, Melbourne, VIC 3010, Australia.
J Phys Chem A. 2006 Jul 13;110(27):8304-15. doi: 10.1021/jp056471v.
The results from an investigation of the collision-induced dissociation (CID) of the ternary complexes Cu(II)(terpy)(AA) are presented (terpy = 2,2':6',2' '-terpyridine; AA = one of the twenty common amino acids). These complexes show a rich gas-phase chemistry, which depends on the identity of the amino acid. For the histidine-, lysine- and tryptophan-containing complexes, oxidative dissociation of the amino acid is observed, yielding the amino acid radical cation. The results of further mass selection and CID of these amino acid radical cations are presented. The CID of the series Fe(III)(salen)(AA) (where salen = N,N'-ethylenebis(salicylideneaminato)) is also examined. These complexes undergo loss of the neutral amino acid in all cases, although the radical cation of arginine is also produced and its subsequent fragmentation examined. B3-LYP/6-31G(d) computations were carried out to test aspects of the proposed fragmentation mechanism of the histidine and arginine radical cations.
本文展示了对三元配合物Cu(II)(三联吡啶)(氨基酸)碰撞诱导解离(CID)的研究结果(三联吡啶= 2,2':6',2''-三联吡啶；氨基酸=二十种常见氨基酸之一)。这些配合物展现出丰富的气相化学性质，这取决于氨基酸的种类。对于含组氨酸、赖氨酸和色氨酸的配合物，观察到氨基酸的氧化解离，生成氨基酸自由基阳离子。本文展示了对这些氨基酸自由基阳离子进一步进行质量选择和CID的结果。同时也研究了Fe(III)(水杨醛缩乙二胺)(氨基酸)系列(其中水杨醛缩乙二胺= N,N'-亚乙基双(水杨醛缩氨基))的CID。在所有情况下，这些配合物都会失去中性氨基酸，不过也会生成精氨酸的自由基阳离子并研究其随后的碎片化过程。进行了B3-LYP/6-31G(d)计算，以检验所提出的组氨酸和精氨酸自由基阳离子碎片化机制的各个方面。
