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老年男性的骨密度、骨几何形态与骨折

Bone density, geometry, and fracture in elderly men.

作者信息

Szulc Pawel

机构信息

INSERM 403 Research Unit, Hôpital Edouard Herriot, Pavillon F, Place d'Arsonval, 69437 Lyon, France.

出版信息

Curr Osteoporos Rep. 2006 Jun;4(2):57-63. doi: 10.1007/s11914-006-0003-8.

Abstract

Bone geometry is a major determinant of the mechanical resistance of bone. Mechanical strength of the vertebrae depends on the cross-sectional area of the vertebral body and on the size of the posterior arch. Smaller bone width is associated with higher risk of stress fracture. A longer femoral neck axis and a more open neck-shaft angle are associated with higher risk of cervical hip fracture. No consistent association between the femoral neck width and the cervical fracture risk was found. Areal bone mineral density (aBMD) is not a good tool for the identification of elderly men with high fracture risk. Fracture risk increases with decreasing aBMD, but only a minority of men who will sustain an osteoporotic fracture are identified by a given threshold of baseline aBMD. Bone width seems to be an independent predictor of the fracture risk in elderly men, and its assessment can improve the prediction of fractures in this population.

摘要

骨几何结构是骨机械抗力的主要决定因素。椎体的机械强度取决于椎体的横截面积和后弓的大小。较小的骨宽度与应力性骨折的较高风险相关。较长的股骨颈轴线和更开放的颈干角与髋部颈椎骨折的较高风险相关。未发现股骨颈宽度与颈椎骨折风险之间存在一致的关联。骨面积密度(aBMD)不是识别骨折风险高的老年男性的良好工具。骨折风险随aBMD降低而增加,但在给定的基线aBMD阈值下,只有少数会发生骨质疏松性骨折的男性能够被识别出来。骨宽度似乎是老年男性骨折风险的独立预测因素,对其进行评估可以改善对该人群骨折的预测。

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