可卡因和苯丙胺调节转录物（CART）与应激反应。
Cocaine and amphetamine regulated transcript (CART) and the stress response.
作者信息
Koylu Ersin O, Balkan Burcu, Kuhar Michael J, Pogun Sakire
机构信息
Ege University Center for Brain Research, Department of Physiology, Bornova, 35100 Izmir, Turkey.
出版信息
Peptides. 2006 Aug;27(8):1956-69. doi: 10.1016/j.peptides.2006.03.032. Epub 2006 Jul 5.
CART is expressed abundantly in the hypothalamic paraventricular nucleus and locus coeruleus, major corticotropin releasing factor (CRF) and noradrenaline sources, respectively. There is a bidirectional relation between CART and hypothalamo-pituitary-adrenal axis activity. CART stimulates CRF, adrenocorticotropic hormone and glucocorticoid secretion, whereas CRF and glucocorticoids increase the transcriptional activity of the CART gene; adrenalectomy declines CART expression in the hypothalamus. Stress exposure modulates CART expression in hypothalamus and amygdala in rat brain in a region and sex specific manner. CART may be a mediator peptide in the interaction between stress, drug abuse, and feeding. The review discusses the established role of CART as it relates to the stress response.
可卡因-安非他明调节转录肽（CART）在下丘脑室旁核和蓝斑中大量表达，分别是促肾上腺皮质激素释放因子（CRF）和去甲肾上腺素的主要来源。CART与下丘脑-垂体-肾上腺轴活动之间存在双向关系。CART刺激CRF、促肾上腺皮质激素和糖皮质激素的分泌，而CRF和糖皮质激素则增加CART基因的转录活性；肾上腺切除术会降低下丘脑CART的表达。应激暴露以区域和性别特异性方式调节大鼠脑中下丘脑和杏仁核的CART表达。CART可能是应激、药物滥用和进食之间相互作用的一种介质肽。本文综述讨论了CART在应激反应中的既定作用。
Zotero 插件