红棕榈油可抑制偶氮甲烷（AOM）诱导的Fisher 344雄性大鼠异常隐窝灶（ACF）的形成。

Red palm oil suppresses the formation of azoxymethane (AOM) induced aberrant crypt foci (ACF) in Fisher 344 male rats.

作者信息

Boateng J, Verghese M, Chawan C B, Shackelford L, Walker L T, Khatiwada J, Williams D S

机构信息

Nutrition Biochemistry and Carcinogenesis Laboratory, Department of Food and Animal Sciences, Alabama A&M University, P.O. Box 1628, Normal, 35762, USA.

出版信息

Food Chem Toxicol. 2006 Oct;44(10):1667-73. doi: 10.1016/j.fct.2006.05.002. Epub 2006 May 17.

DOI:10.1016/j.fct.2006.05.002

PMID:16822603

Abstract

Red palm oil (RPO) contains significant levels of carotenoids and Vitamin E. In this experiment we compared the inhibitory effects of RPO (7% and 14% levels) and soybean oil (7% and 14%) on azoxymethane (AOM) induced aberrant crypt foci (ACF). Thirty-two male Fisher 344 rats were randomly assigned to four groups. Two groups received AIN-93 G control (C) diet containing 7% and 14% soybean oil (SBO), respectively. Groups 3 and 4 received a treatment diet consisting of 7% and 14% RPO, respectively. The rats received subcutaneous injections of AOM at 16 mg/kg body weight at 7 and 8 weeks of age. At 17 weeks of age rats were killed by CO(2) asphyxiation. Numbers of ACF (mean+/-SE) in the proximal and distal colon were: 39.9 +/- 0.9, 53.8 +/- 2.8, 26.0 +/- 3.0, 27.5 +/- 1.5 and 118.2 +/- 1.7, 125.6 +/- 3.2, 41 +/- 7, 52.3 +/- 1.8 in rats fed 7% SBO, 14% SBO, 7% RPO and 14% RPO, respectively. The results of this study showed that RPO reduced the incidence of AOM induced ACF and may therefore have a beneficial effect in reducing the incidence of colon cancer.

摘要

红棕榈油（RPO）含有大量类胡萝卜素和维生素E。在本实验中，我们比较了RPO（7%和14%含量）和大豆油（7%和14%）对乙基亚硝基脲（AOM）诱导的异常隐窝灶（ACF）的抑制作用。32只雄性Fisher 344大鼠被随机分为四组。两组分别接受含有7%和14%大豆油（SBO）的AIN-93 G对照（C）饮食。第3组和第4组分别接受由7%和14% RPO组成的治疗饮食。大鼠在7周和8周龄时接受16 mg/kg体重的AOM皮下注射。在17周龄时，大鼠通过二氧化碳窒息处死。近端和远端结肠中ACF的数量（平均值±标准误）分别为：喂食7% SBO、14% SBO、7% RPO和14% RPO的大鼠中，ACF数量分别为39.9±0.9、53.8±2.8、26.0±3.0、27.5±1.5以及118.2±1.7、125.6±3.2、41±7、52.3±1.8。本研究结果表明，RPO降低了AOM诱导的ACF发生率，因此可能对降低结肠癌发病率具有有益作用。