Gourineni V P, Verghese M, Boateng J, Shackelford L, Bhat N K, Walker L T
Nutrition Biochemistry and Carcinogenesis Laboratory, Department of Food and Animal Sciences, Alabama A&M University, Normal, AL 35762, USA.
J Nutr Metab. 2011;2011:868197. doi: 10.1155/2011/868197. Epub 2011 Sep 26.
Prebiotic fructans are nondigestible carbohydrates with numerous health benefits. Soybean is a rich source of phytonutrients such as isoflavones. The objective of this study was to evaluate the chemopreventive effects of prebiotics (Synergy1) and soybean meal (SM) at 5% and 10% levels alone and in combination on azoxymethane- (AOM-) induced colon carcinogenesis. After one wk of acclimatization, Fisher 344 male rats (N = 90) were randomly assigned to 9 groups (n = 10). Control rats (C) were fed AIN-93G/M. Two s/c injections of AOM were administered to rats at 7 and 8 wk of age at 16 mg/kg body weight. Rats were killed by CO(2) asphyxiation at 45 wk. Tumor incidence (%) in treatment groups ranged from 40 to 75 compared to 100 in C. Results indicate that feeding prebiotics and soybean in combination significantly reduced incidence of AOM-induced colon tumors with implications for food industry in the food-product development.
益生元果聚糖是具有多种健康益处的不可消化碳水化合物。大豆是异黄酮等植物营养素的丰富来源。本研究的目的是评估单独及联合使用5%和10%水平的益生元（协同1）和豆粕（SM）对氧化偶氮甲烷（AOM）诱导的结肠癌发生的化学预防作用。适应一周后，将90只雄性Fisher 344大鼠随机分为9组（每组10只）。对照大鼠（C组）喂食AIN-93G/M。在7周和8周龄时，给大鼠皮下注射两次AOM，剂量为16 mg/kg体重。在45周时，通过二氧化碳窒息法处死大鼠。与C组的100%相比，治疗组的肿瘤发生率（%）在40%至75%之间。结果表明，联合喂食益生元和大豆可显著降低AOM诱导的结肠肿瘤发生率，这对食品工业的食品开发具有重要意义。
