Pohl A, Otto J, Urbanek R
Department of Pediatrics, University of Freiburg, FRG.
Int Arch Allergy Appl Immunol. 1991;95(2-3):261-5. doi: 10.1159/000235439.
[125I]-cyanopindolol (ICYP) was used in a binding assay to compare the number and affinity of beta 2-adrenoceptor binding sites on circulating polymorphonuclear leukocytes (PMN) of 21 children with atopic dermatitis (AD) and 23 age-matched controls. We found no correlation between the beta 2-adrenoceptor density and the age of the children in either collective. Furthermore, the number and affinity of beta 2-adrenoceptor binding sites on PMN was neither influenced by sex nor severity of disease, serum IgE level or percentage of eosinophils in the differential blood count. There was a tendency towards a lower number of beta 2-adrenoceptors in AD subjects (1,429 +/- 587 receptors/PMN) compared to controls (1,753 +/- 596 receptors/PMN), but this difference was statistically not significant.
使用[125I]-氰基吲哚洛尔（ICYP）进行结合试验，以比较21例特应性皮炎（AD）患儿和23例年龄匹配的对照者循环多形核白细胞（PMN）上β2-肾上腺素能受体结合位点的数量和亲和力。我们发现，在任何一组中，β2-肾上腺素能受体密度与儿童年龄之间均无相关性。此外，PMN上β2-肾上腺素能受体结合位点的数量和亲和力既不受性别影响，也不受疾病严重程度、血清IgE水平或白细胞分类计数中嗜酸性粒细胞百分比的影响。与对照组（1753±596个受体/PMN）相比，AD患者的β2-肾上腺素能受体数量有减少的趋势（1429±587个受体/PMN），但这种差异在统计学上不显著。
