de Jong Paul E, Curhan Gary C
Division of Nephrology, Department of Medicine, University Medical Center Groningen, Groningen University, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
J Am Soc Nephrol. 2006 Aug;17(8):2120-6. doi: 10.1681/ASN.2006010097. Epub 2006 Jul 6.
Microalbuminuria is an early sign of progressive cardiovascular and renal disease in individuals with and without diabetes. Despite compelling data, at present only a minority of patients with diabetes and rarely individuals without diabetes are screened for albuminuria in a systematic way. All of the criteria to implement systematic albuminuria screening are fulfilled in diabetes, and most are nearly fulfilled for microalbuminuria screening in individuals without diabetes. Because of the growing evidence that treatment of microalbuminuria in individuals without diabetes may offer a cost-effective benefit to prevent cardiovascular disease, nephrologists and other health care providers should pay more attention to the early detection and subsequent treatment of individuals with microalbuminuria.
微量白蛋白尿是糖尿病患者和非糖尿病患者心血管和肾脏疾病进展的早期迹象。尽管有确凿的数据,但目前只有少数糖尿病患者会接受系统性的白蛋白尿筛查,非糖尿病患者则很少接受此类筛查。糖尿病患者具备实施系统性白蛋白尿筛查的所有条件,而大多数非糖尿病患者也几乎满足微量白蛋白尿筛查的条件。鉴于越来越多的证据表明,治疗非糖尿病患者的微量白蛋白尿可能在预防心血管疾病方面带来具有成本效益的益处,肾病学家和其他医疗服务提供者应更加关注微量白蛋白尿患者的早期检测及后续治疗。