胸腺肽α1通过激活细胞外信号调节激酶1/2（ERK1/2）、应激活化蛋白激酶（JNK）以及增加人胰腺癌细胞中的细胞因子分泌来刺激细胞增殖。
Thymosinalpha1 stimulates cell proliferation by activating ERK1/2, JNK, and increasing cytokine secretion in human pancreatic cancer cells.
作者信息
Li Min, Feurino Louis W, Li Fei, Wang Hao, Zhai Qihui, Fisher William E, Chen Changyi, Yao Qizhi
机构信息
Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Cancer Lett. 2007 Apr 8;248(1):58-67. doi: 10.1016/j.canlet.2006.05.019. Epub 2006 Jul 7.
In this study, we investigated the expression and function of thymosinalpha1 (Thyalpha1) in human pancreatic cancer. We found that human pancreatic cancer cell lines Panc-1, Panc03.27, ASPC-1, and PL45 cells significantly over-expressed the mRNA of Thyalpha1 as compared to the normal human pancreatic ductal epithelium (HPDE) cells.. Thyalpha1 mRNA and protein levels were also over-expressed in clinical pancreatic adenocarcinoma specimens. In addition, synthetic Thyalpha1 significantly promoted Panc-1 cell proliferation and increased phosphorylation of ERK1/2 and JNK. Furthermore, Thyalpha1 increased the secretion of multiple cytokines including IL-10, IL-13, and IL-17 in Panc-1 cells. Thus, Thyalpha1 may have a new role in pancreatic cancer pathogenesis.
在本研究中，我们调查了胸腺肽α1（Thyα1）在人类胰腺癌中的表达及功能。我们发现，与正常人类胰腺导管上皮（HPDE）细胞相比，人类胰腺癌细胞系Panc-1、Panc03.27、ASPC-1和PL45细胞显著过度表达Thyα1的mRNA。Thyα1的mRNA和蛋白水平在临床胰腺腺癌标本中也呈过度表达。此外，合成的Thyα1显著促进Panc-1细胞增殖，并增加ERK1/2和JNK的磷酸化。此外，Thyα1增加了Panc-1细胞中包括IL-10、IL-13和IL-17在内的多种细胞因子的分泌。因此，Thyα1可能在胰腺癌发病机制中具有新作用。
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