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IL-4、IL-13 及其受体在胰腺癌中的作用。

Involvement of IL-4, IL-13 and Their Receptors in Pancreatic Cancer.

机构信息

Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, 89081 Ulm, Germany.

出版信息

Int J Mol Sci. 2021 Mar 15;22(6):2998. doi: 10.3390/ijms22062998.

DOI:10.3390/ijms22062998
PMID:33804263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8000536/
Abstract

Interleukin (IL)-4 and IL-13 are known as pleiotropic Th2 cytokines with a wide range of biological properties and functions especially in immune responses. In addition, increasing activities have also been determined in oncogenesis and tumor progression of several malignancies. It is now generally accepted that IL-4 and IL-13 can exert effects on epithelial tumor cells through corresponding receptors. Type II IL-4 receptor (IL-4Rα/IL-13Rα1), predominantly expressed in non-hematopoietic cells, is identified to be the main target for both IL-4 and IL-13 in tumors. Moreover, IL-13 can also signal by binding to the IL-13Rα2 receptor. Structural similarity due to the use of the same receptor complex generated in response to IL-4/IL-13 results in overlapping but also distinct signaling pathways and functions. The aim of this review was to summarize knowledge about IL-4 and IL-13 and their receptors in pancreatic cancer in order understand the implication of IL-4 and IL-13 and their receptors for pancreatic tumorigenesis and progression and for developing possible new diagnostic and therapeutic targets.

摘要

白细胞介素 (IL)-4 和 IL-13 是具有广泛生物学特性和功能的多功能 Th2 细胞因子，特别是在免疫反应中。此外，在几种恶性肿瘤的致癌作用和肿瘤进展中也确定了活性增加。现在普遍认为，IL-4 和 IL-13 可以通过相应的受体对上皮肿瘤细胞发挥作用。II 型白细胞介素 4 受体 (IL-4Rα/IL-13Rα1) 主要在非造血细胞中表达，被确定为肿瘤中 IL-4 和 IL-13 的主要靶标。此外，IL-13 还可以通过与 IL-13Rα2 受体结合而发出信号。由于对 IL-4/IL-13 的反应使用相同的受体复合物，因此产生了结构相似性，导致重叠但又不同的信号通路和功能。本综述的目的是总结有关 IL-4 和 IL-13 及其在胰腺癌中的受体的知识，以便了解 IL-4 和 IL-13 及其受体对胰腺肿瘤发生和进展的影响，并为开发可能的新的诊断和治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc9/8000536/8d22c9eb6692/ijms-22-02998-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc9/8000536/3c040465790f/ijms-22-02998-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc9/8000536/e6ba6056b3fe/ijms-22-02998-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc9/8000536/8d22c9eb6692/ijms-22-02998-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc9/8000536/3c040465790f/ijms-22-02998-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc9/8000536/e6ba6056b3fe/ijms-22-02998-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc9/8000536/8d22c9eb6692/ijms-22-02998-g003.jpg

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本文引用的文献

[1]
Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer.

Int J Mol Sci. 2021-1-13

[2]
A Novel Role of Interleukin 13 Receptor alpha2 in Perineural Invasion and its Association with Poor Prognosis of Patients with Pancreatic Ductal Adenocarcinoma.

Cancers (Basel). 2020-5-20

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Genes Immun. 2020-5

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J Cachexia Sarcopenia Muscle. 2020-6

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J Radiat Res. 2020-5-22

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Expert Opin Biol Ther. 2020-1-20

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CA Cancer J Clin. 2020-1-8

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Medicina (Kaunas). 2019-12-30

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Legumain Promotes Gastric Cancer Progression Through Tumor-associated Macrophages and .

Int J Biol Sci. 2020-1-1

[10]
Activation of the IL-4/STAT6 Signaling Pathway Promotes Lung Cancer Progression by Increasing M2 Myeloid Cells.

Front Immunol. 2019-11-13

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