Yong-Zhong G, van Alphen H A
Department of Neurosurgery, Free University Hospital, Amsterdam, The Netherlands.
Neurol Res. 1991 Jun;13(2):103-6. doi: 10.1080/01616412.1991.11739974.
In experimental studies, permanent hypertension has been considered to be an important factor in aneurysm formation and growth. However, in clinical studies it has been found that saccular aneurysms often develop and rupture in some patients without persistent hypertension. Environmental events that temporarily and repeatedly increase blood pressure do not take an equivalent length of time in vivo but have been noted as factors in the growth or rupture of saccular aneurysms. In order to test the effect of intermittent blood pressure elevations on saccular aneurysm formation and growth, a reliable method for temporarily and repeatedly increasing blood pressure should be developed first and in this paper, such a model is described. It is based on the intraperitoneal injections of adrenaline in rats, a route which does not seem to have been used so far.
在实验研究中，持续性高血压被认为是动脉瘤形成和生长的一个重要因素。然而，在临床研究中发现，一些无持续性高血压的患者常发生囊状动脉瘤并破裂。能暂时且反复升高血压的环境因素在体内作用的时间并不相同，但已被视为囊状动脉瘤生长或破裂的因素。为了测试间歇性血压升高对囊状动脉瘤形成和生长的影响，首先应开发一种可靠的方法来暂时且反复升高血压，本文描述了这样一种模型。它基于给大鼠腹腔注射肾上腺素，这一途径似乎迄今尚未被使用过。
