Dupont-Mairesse N, Galand P
J Endocrinol. 1975 May;65(2):215-8. doi: 10.1677/joe.0.0650215.
While there is conflicting evidence concerning an effect of oestradiol on uterine cyclic AMP concentration, results from different laboratories (including ours) are in agreement that even when observed, the early increase in uterine cyclic AMP after oestradiol injection fails to occur when propranolol, a beta-adrenergic blocking agent, is given (50 mug, i.p.) 20 min before the oestradiol. The present work shows that pretreatment with propranolol failed to inhibit an early uterine response to oestradiol, namely the synthesis after 1 h of uterine protein, or class of proteins, IP. It is concluded that the induction of IP by oestradiol does not depend on an increase in uterine cyclic AMP concentration and that beta-adrenergic receptors do not have a role in this oestrogenic response.
虽然关于雌二醇对子宫环磷酸腺苷（cAMP）浓度的影响存在相互矛盾的证据，但不同实验室（包括我们的实验室）的结果一致表明，即使观察到，在注射雌二醇前20分钟腹腔注射50微克β-肾上腺素能阻滞剂普萘洛尔后，注射雌二醇后子宫cAMP的早期升高也不会出现。目前的研究表明，用普萘洛尔预处理未能抑制子宫对雌二醇的早期反应，即1小时后子宫蛋白或IP类蛋白的合成。得出的结论是，雌二醇诱导IP并不依赖于子宫cAMP浓度的升高，并且β-肾上腺素能受体在这种雌激素反应中不起作用。
