血清β-人绒毛膜促性腺激素水平与子痫前期

Serum beta human chorionic gonadotropin levels and preeclampsia.

作者信息

Basirat Zahra, Barat Shahnaz, Hajiahmadi Mahmood

机构信息

Department of Gynecology, Yahyanejad Hospital, Babol Medical University, Babol, Postal Code: 4713655647, Iran.

出版信息

Saudi Med J. 2006 Jul;27(7):1001-4.

PMID:16830019

Abstract

OBJECTIVE

Preeclampsia is one of the most common complications of pregnancy. It is a trophoblastic disorder. Since human chorionic gonadotropin (hCG) is secreted by trophoblast, the purpose of the study was to determine the levels of beta (hCG) in preeclampsia and normal cases.

METHODS

This study was conducted on 40 term pregnant women with preeclampsia (case group) and 40 normal pregnant cases (control group) in the Department of Obstetrics and Gynecology, Medical University, Babol, Iran, from 2004 to 2005. Serum beta-hCG in all cases were measured by radioimmunoassay. The mean beta-hCG level in preeclampsia (mild and severe) was compared with normal cases.

RESULTS

The maternal serum, beta-hCG level in patients with preeclampsia (39840 +/- 24630 IU/L) was higher than in the control group (27460 +/- 25862 IU/L) (p=0.031). In mild preeclampsia (34 cases), the mean serum beta-hCG level was 31991 +/- 16758 IU/L while in severe preeclampsia (6 cases) 84312 +/- 9257 IU/L (p<0.0001). The mean serum beta-hCG level in mild and severe preeclampsia was higher compared to the normal cases.

CONCLUSION

The results of this study show that the levels of beta-hCG in severe form of preeclampsia is higher compared to the milder ones.

摘要

目的

子痫前期是妊娠最常见的并发症之一。它是一种滋养细胞疾病。由于人绒毛膜促性腺激素（hCG）由滋养细胞分泌，本研究的目的是测定子痫前期患者和正常孕妇体内β-hCG的水平。

方法

本研究于2004年至2005年在伊朗巴博勒医科大学妇产科对40例足月子痫前期孕妇（病例组）和40例正常孕妇（对照组）进行。所有病例的血清β-hCG均采用放射免疫法测定。将子痫前期（轻度和重度）患者的β-hCG平均水平与正常孕妇进行比较。

结果

子痫前期患者的母体血清β-hCG水平（39840±24630 IU/L）高于对照组（27460±25862 IU/L）（p=0.031）。轻度子痫前期（34例）患者的血清β-hCG平均水平为31991±16758 IU/L，而重度子痫前期（6例）患者为84312±9257 IU/L（p<0.0001）。与正常孕妇相比，轻度和重度子痫前期患者的血清β-hCG平均水平更高。