[足月妊娠妇女及妊娠期高血压疾病患者母血与胎盘组织中HCG的临床意义]
[Clinical significance of HCG in both maternal serum and placental tissue in normal term women and patients with pregnancy induced hypertension].
作者信息
Yin B
机构信息
Maternity and Child Health of Zhuhai.
出版信息
Zhonghua Yi Xue Za Zhi. 1997 Aug;77(8):589-91.
OBJECTIVE
To determine the maternal serum level of HCG beta and the hormones in normal term women and patients with pregnancy induced hypertension.
METHOD
Semiquantitative immunohistochemistry of placental tissue was used in 193 normal term women and patients with pregnancy-induced hypertension (PIH).
RESULTS
A strongly positive correlation between the maternal serum level of HCG and the immunostained positive syncytiotrophoblasts (ST) was found (correlated coefficient: 0.65, P < 0.01). Maternal serum HCG was produced mainly from placental ST. Serum HCG beta and HCG positive cells of the placenta were obviously higher in patients with PIH than those in normal term women (P < 0.01). An increase of HCG level was noted in maternal serum and the placental tissue with PIH.
CONCLUSION
Abnormal higher HCG level may affect the pathogenesis of PIH.
目的
测定足月正常孕妇及妊娠高血压综合征患者血清中β-人绒毛膜促性腺激素（HCG）及其他激素水平。
方法
采用半定量免疫组织化学方法检测193例足月正常孕妇及妊娠高血压综合征（PIH）患者胎盘组织。
结果
孕妇血清HCG水平与免疫染色阳性的合体滋养层细胞（ST）呈强正相关（相关系数：0.65，P<0.01）。孕妇血清HCG主要由胎盘ST产生。PIH患者血清β-HCG及胎盘HCG阳性细胞明显高于足月正常孕妇（P<0.01）。PIH患者母血及胎盘组织中HCG水平升高。
结论
异常升高的HCG水平可能影响PIH的发病机制。
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