Marchisio M, Bertagnolo V, Lanuti P, Gaspari A R, Paludi M, Ciccocioppo F, Ercolino E, Bascelli A, Cataldi A, Miscia S
Cell Signalling Unit at the Department of Biomorphology, University of Chieti-Pescara, Italy.
Int J Immunopathol Pharmacol. 2006 Apr-Jun;19(2):287-91. doi: 10.1177/039463200601900206.
Protein kinase Cs (PKCs) belong to a serine/threonine kinase family, ubiquitously expressed and claimed to be involved in physiological processes including apoptosis, cell growth and differentiation. The question of the subcellular localization and activity of PKCs remains to be clarified. Here we report that nuclear PKC-delta cooperates to regulate the S-G2/M phase transition of cell cycle, apparently being associated to chromosome condensation and alignment on the metaphase plate.
蛋白激酶C（PKC）属于丝氨酸/苏氨酸激酶家族，广泛表达，据称参与包括细胞凋亡、细胞生长和分化在内的生理过程。PKC的亚细胞定位和活性问题仍有待阐明。在此我们报告，核内PKC-δ协同调节细胞周期的S-G2/M期转换，显然与染色体凝聚和在中期板上的排列有关。
