Albuquerque Marco Antonio Portela, Melo Ediele Santana, Jorge Waldyr Antonio, Cavalcanti Marcelo Gusmão Paraiso
Department of Oral Diagnosis, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Jul;102(1):94-8. doi: 10.1016/j.tripleo.2005.08.019. Epub 2006 Mar 3.
Osteopetrosis is a rare hereditary bone disorder presenting with variable clinical features and is characterized by an increase in bone density. The main clinical findings of the benign-type of osteopetrosis (autosomal dominant) are fractures and osteomyelitis of the mandible, leading to the detection of the disease. We report a case of autosomal dominant osteopetrosis with secondary mandibular osteomyelitis. Clinical and radiological patterns and treatment evaluation were assessed. The patient was referred for evaluation and treatment of an acute abscess in the left side of the face and osteomyelitis of the mandible. Several imaging studies were performed to assess the lesion and the adjacent bone and soft tissue structures. Treatment consisted of intravenous antibiotic therapy, debridement of the necrotic bone and sequestrum, and extra-oral drainage of the abscess, with submandibular access. Healing was uneventful.
骨硬化症是一种罕见的遗传性骨病，临床表现多样，其特征是骨密度增加。良性型骨硬化症（常染色体显性遗传）的主要临床发现是下颌骨骨折和骨髓炎，由此得以诊断该病。我们报告一例常染色体显性遗传性骨硬化症继发下颌骨骨髓炎的病例。评估了其临床和放射学表现及治疗效果。该患者因左侧面部急性脓肿和下颌骨骨髓炎前来接受评估和治疗。进行了多项影像学检查以评估病变及相邻的骨骼和软组织结构。治疗包括静脉抗生素治疗、坏死骨和死骨清除术以及脓肿的口外引流，采用下颌下入路。愈合过程顺利。
