Eriksson L S, Reihnér E, Wahren J
Departments of Internal Medicine, Surgery and Clinical Physiology, Huddinge University Hospital, S-141 86 Stockholm, Sweden.
Clin Nutr. 1985 May;4(2):73-6. doi: 10.1016/0261-5614(85)90045-7.
Infusion of ornithine-alpha-ketoglutarate (Ornicetil) has been suggested to improve nitrogen balance in trauma patients. Whether this anticatabolic effect is localised to the liver or to skeletal muscle is as yet unknown. Consequently, the splanchnic and leg exchange of amino acids, urea and ammonia were measured in seven healthy non-obese subjects in the basal state and during infusion of ornithine-alpha-ketoglutarate at a rate of 28 mg/min for 150 min. The results demonstrate a six-fold rise in arterial ornithine and an increased uptake by both splanchnic and leg tissues during infusion. The splanchnic uptake of threonine and lysine also increased, while no other alterations were seen in leg amino acid exchange. The arterial urea concentration decreased slightly (-6%, P<0.01) during the infusion in spite of an unchanged urea production from the liver. The ammonia concentration fell by 20% (P<0.05), while glycerol and ketone body concentrations did not change significantly. It is concluded that intravenous infusion of ornithine-alpha-ketoglutarate in healthy subjects does not significantly influence hepatic or skeletal muscle protein metabolism.
有人提出输注鸟氨酸α-酮戊二酸（门冬氨酸鸟氨酸）可改善创伤患者的氮平衡。这种抗分解代谢作用是局限于肝脏还是骨骼肌，目前尚不清楚。因此，我们对7名健康非肥胖受试者在基础状态下以及以28毫克/分钟的速率输注鸟氨酸α-酮戊二酸150分钟期间的内脏和腿部氨基酸、尿素及氨的交换情况进行了测定。结果显示，输注期间动脉血鸟氨酸升高了6倍，内脏和腿部组织的摄取均增加。内脏对苏氨酸和赖氨酸的摄取也增加，而腿部氨基酸交换未见其他变化。尽管肝脏尿素生成未变，但输注期间动脉血尿素浓度略有下降（-6%，P<0.01）。氨浓度下降了20%（P<0.05），而甘油和酮体浓度无明显变化。结论是，在健康受试者中静脉输注鸟氨酸α-酮戊二酸不会显著影响肝脏或骨骼肌的蛋白质代谢。
