Schweizer Jürgen, Bowden Paul E, Coulombe Pierre A, Langbein Lutz, Lane E Birgitte, Magin Thomas M, Maltais Lois, Omary M Bishr, Parry David A D, Rogers Michael A, Wright Mathew W
Section of Normal and Neoplastic Epidermal Differentiation, Division of Cell Biology, German Cancer Research Center, 69120 Heidelberg, Germany.
J Cell Biol. 2006 Jul 17;174(2):169-74. doi: 10.1083/jcb.200603161. Epub 2006 Jul 10.
Keratins are intermediate filament-forming proteins that provide mechanical support and fulfill a variety of additional functions in epithelial cells. In 1982, a nomenclature was devised to name the keratin proteins that were known at that point. The systematic sequencing of the human genome in recent years uncovered the existence of several novel keratin genes and their encoded proteins. Their naming could not be adequately handled in the context of the original system. We propose a new consensus nomenclature for keratin genes and proteins that relies upon and extends the 1982 system and adheres to the guidelines issued by the Human and Mouse Genome Nomenclature Committees. This revised nomenclature accommodates functional genes and pseudogenes, and although designed specifically for the full complement of human keratins, it offers the flexibility needed to incorporate additional keratins from other mammalian species.
角蛋白是形成中间丝的蛋白质，可提供机械支持并在上皮细胞中发挥多种其他功能。1982年，人们设计了一种命名法来命名当时已知的角蛋白。近年来，人类基因组的系统测序发现了几个新的角蛋白基因及其编码的蛋白质。在原始系统的背景下，它们的命名无法得到妥善处理。我们提出了一种新的角蛋白基因和蛋白质的共识命名法，该命名法依赖并扩展了1982年的系统，并遵循了人类和小鼠基因组命名委员会发布的指南。这种修订后的命名法适用于功能基因和假基因，虽然是专门为人类角蛋白的完整补充而设计的，但它提供了纳入其他哺乳动物物种的额外角蛋白所需的灵活性。
