Teitelbaum Steven L
Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Ann N Y Acad Sci. 2006 Apr;1068:95-9. doi: 10.1196/annals.1346.017.
The osteoclast is the unique bone resorptive cell that accomplishes its mission by forming an isolated acidified microenvironment between itself and the bone surface. Creation of this compartment is the first step in bone degradation and establishes that an intimate physical relationship must exist between the osteoclast and bone. Thus, identification of the mechanisms by which the osteoclast attaches to bone is essential to understanding how the cell degrades skeletal tissue. Our studies have investigated whether absence of the alphavbeta3 integrin modifies the ability of c-Fms to induce Rho GTPases, and the implications for formation of the osteoclast cytoskeleton.
破骨细胞是独特的骨吸收细胞，它通过在自身与骨表面之间形成一个孤立的酸化微环境来完成其使命。创建这个区室是骨降解的第一步，并表明破骨细胞与骨之间必须存在密切的物理关系。因此，确定破骨细胞附着于骨的机制对于理解该细胞如何降解骨骼组织至关重要。我们的研究调查了αvβ3整合素的缺失是否会改变c-Fms诱导Rho GTP酶的能力，以及对破骨细胞细胞骨架形成的影响。
