Didelot-Rousseau M-N, Nagot N, Costes-Martineau V, Vallès X, Ouedraogo A, Konate I, Weiss H A, Van de Perre P, Mayaud P, Segondy M
Department of Virology, Montpellier University Hospital, 34295 Montpellier, France.
Br J Cancer. 2006 Aug 7;95(3):355-62. doi: 10.1038/sj.bjc.6603252. Epub 2006 Jul 11.
Human papillomavirus (HPV) infection and cervical squamous intraepithelial lesions (SILs) were studied in 379 high-risk women. Human papillomavirus DNA was detected in 238 of 360 (66.1%) of the beta-globin-positive cervical samples, and 467 HPV isolates belonging to 35 types were identified. Multiple (2-7 types) HPV infections were observed in 52.9% of HPV-infected women. The most prevalent HPV types were HPV-52 (14.7%), HPV-35 (9.4%), HPV-58 (9.4%), HPV-51 (8.6%), HPV-16 (7.8%), HPV-31 (7.5%), HPV-53 (6.7%), and HPV-18 (6.4%). Human immunodeficiency virus type 1 (HIV-1) seroprevalence was 36.0%. Human papillomavirus prevalence was significantly higher in HIV-1-infected women (87 vs 54%, prevalence ratio (PR) = 1.61, 95% confidence interval (CI): 1.4-1.8). High-risk HPV types (71 vs 40%, PR = 1.79, 95% CI: 1.5-2.2), in particular HPV-16+18 (22 vs 9%, PR = 2.35, 95% CI: 1.4-4.0), and multiple HPV infections (56 vs 23%, PR = 2.45, 95% CI: 1.8-3.3) were more prevalent in HIV-1-infected women. High-grade SIL (HSIL) was identified in 3.8% of the women. Human immunodeficiency virus type 1 infection was strongly associated with presence of HSIL (adjusted odds ratio = 17.0; 95% CI 2.2-134.1, P = 0.007) after controlling for high-risk HPV infection and other risk factors for HSIL. Nine of 14 (63%) HSIL cases were associated with HPV-16 or HPV-18 infection, and might have been prevented by an effective HPV-16/18 vaccine.
对379名高危女性进行了人乳头瘤病毒（HPV）感染和宫颈鳞状上皮内病变（SILs）的研究。在360份β-珠蛋白阳性宫颈样本中的238份（66.1%）检测到HPV DNA，鉴定出属于35种类型的467株HPV分离株。在52.9%的HPV感染女性中观察到多重（2 - 7种类型）HPV感染。最常见的HPV类型为HPV - 52（14.7%）、HPV - 35（9.4%）、HPV - 58（9.4%）、HPV - 51（8.6%）、HPV - 16（7.8%）、HPV - 31（7.5%）、HPV - 53（6.7%）和HPV - 18（6.4%）。1型人类免疫缺陷病毒（HIV - 1）血清阳性率为36.0%。HIV - 1感染女性中的HPV感染率显著更高（87%对54%，患病率比（PR）=1.61，95%置信区间（CI）：1.4 - 1.8）。高危HPV类型（71%对40%，PR = 1.79，95% CI：1.5 - 2.2），特别是HPV - 16 + 18（22%对9%，PR = 2.35，95% CI：1.4 - 4.0）以及多重HPV感染（56%对23%，PR = 2.45，95% CI：1.8 - 3.3）在HIV - 1感染女性中更为普遍。3.8%的女性被鉴定为高级别SIL（HSIL）。在控制了高危HPV感染和其他HSIL风险因素后，1型人类免疫缺陷病毒感染与HSIL的存在密切相关（调整后的优势比 = 17.0；95% CI 2.2 - 134.1，P = 0.007）。14例HSIL病例中有9例（63%）与HPV - 16或HPV - 18感染相关，可能可通过有效的HPV - 16/18疫苗预防。
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