Teraki Y, Shiohara T, Nagashima M, Nishikawa T
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
Br J Dermatol. 1991 Oct;125(4):360-3. doi: 10.1111/j.1365-2133.1991.tb14172.x.
Immunohistochemical studies were carried out on the skin lesions of two cases of prurigo pigmentosa. There was a predominance of CD4+ cells in the dermal infiltrate, whereas those lymphocytes in the epidermis were mainly CD8+ cells. The majority of dermal and epidermotropic lymphocytes showed an intense expression of lymphocyte function-associated antigen 1 (LFA-1). The number of CD1+ cells was increased in the epidermis. There was intense expression of ICAM-1 by keratinocytes in the erythematous papules. Focal expression of ICAM-1 was still observed in the residual pigmented areas and could explain the recurrence of the lesions at these sites.
对两例色素性痒疹患者的皮肤损害进行了免疫组织化学研究。真皮浸润中以CD4+细胞为主，而表皮中的淋巴细胞主要是CD8+细胞。大多数真皮和向表皮性淋巴细胞显示淋巴细胞功能相关抗原1（LFA-1）的强烈表达。表皮中CD1+细胞数量增加。红斑丘疹中的角质形成细胞有ICAM-1的强烈表达。在残留的色素沉着区域仍观察到ICAM-1的局灶性表达，这可以解释这些部位皮损的复发。
