光化性痒疹中的淋巴细胞亚群及黏附分子：环孢素A的观察结果

Lymphocyte subtypes and adhesion molecules in actinic prurigo: observations with cyclosporin A.

作者信息

Umaña Angela, Gómez Alberto, Durán María Mélida, Porras Luisa

机构信息

Instituto de Genética Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Carrera 7 No. 40-62, Bogotá, Colombia.

出版信息

Int J Dermatol. 2002 Mar;41(3):139-45. doi: 10.1046/j.1365-4362.2002.01419.x.

DOI:10.1046/j.1365-4362.2002.01419.x

PMID:12010338

Abstract

BACKGROUND

Actinic prurigo is a photodermatitis in which UV light is implicated by an unknown mechanism.

METHODS

Skin biopsies of 19 patients with actinic prurigo and 11 controls were analyzed by immunohistochemistry.

RESULTS

In actinic prurigo patients, there was a significant increase in the number of CD3, CD4, CD8, CD45RA, CD45RO, and CD45RB lymphocytes and Langerhans cells, as well as in the level of human leukocyte antigen-DR (HLA-DR) expression and cell adhesion molecules lymphocyte functional antigen-1 (LFA-1), intercellular adhesion molecule-1 (ICAM-1), and endothelial leukocyte adhesion molecule-1 (ELAM-1). Actinic prurigo patients were treated with cyclosporin A (CsA), and a final skin biopsy was taken after 6 months of treatment. All the cell populations and markers studied, except for the CD4 lymphocytes, Langerhans cells, and HLA-DR expression, returned to normal levels.

CONCLUSIONS

CsA was found to be effective in relieving the clinical symptoms of actinic prurigo.

摘要

背景

光化性痒疹是一种光性皮炎，紫外线通过未知机制与之相关。

方法

对19例光化性痒疹患者和11例对照者的皮肤活检标本进行免疫组织化学分析。

结果

光化性痒疹患者中，CD3、CD4、CD8、CD45RA、CD45RO和CD45RB淋巴细胞以及朗格汉斯细胞的数量显著增加，人类白细胞抗原-DR（HLA-DR）表达水平以及细胞黏附分子淋巴细胞功能相关抗原-1（LFA-1）、细胞间黏附分子-1（ICAM-1）和内皮白细胞黏附分子-1（ELAM-1）也显著增加。光化性痒疹患者接受环孢素A（CsA）治疗，治疗6个月后进行最终的皮肤活检。除CD4淋巴细胞、朗格汉斯细胞和HLA-DR表达外，所有研究的细胞群体和标志物均恢复到正常水平。