Papadimitrou J M, Woods A E
J Pathol. 1975 Jun;116(2):65-72. doi: 10.1002/path.1711160202.
The microcirculation in a transplantable rat fibrosarcoma was investigated. The vasculature of the neoplasm consisted of irregular channels lined by plump endothelium which displayed mainly pentalaminar although a few heptalaminar junctions were also found. Few pericytes surround the endothelial layer while the basement-membrane varied in thickness and was often duplicated and triplicated. Challenge with histamine resulted in increased permeability in comparison with normal connective tissues similarly treated. The increased permeability was accompanied by the formation of interendothelial gaps in these irregular vascular channels. Carrageenan induced a leucocytic exudate in the neoplasm which, apart from an increase in the mononuclear concentration 2 wk after injection, varied little from normal connective tissues. It is concluded that the majority of vascular channels in this neoplasm bear some structural and functional relationship to small venules.
对可移植大鼠纤维肉瘤的微循环进行了研究。肿瘤的脉管系统由不规则通道组成，通道内衬有丰满的内皮细胞，主要呈现五板层结构，不过也发现了一些七板层连接。很少有周细胞围绕在内皮层周围，而基底膜厚度不一，且常常出现双层和三层结构。与同样处理的正常结缔组织相比，组胺刺激导致通透性增加。通透性增加伴随着这些不规则血管通道内内皮细胞间隙的形成。角叉菜胶在肿瘤中诱导了白细胞渗出，除注射后2周单核细胞浓度增加外，与正常结缔组织相比变化不大。得出的结论是，该肿瘤中的大多数血管通道与小静脉存在一些结构和功能上的关系。
