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儿童癫痫手术中的认知评估。

Cognitive assessment in epilepsy surgery of children.

作者信息

Battaglia D, Chieffo D, Lettori D, Perrino F, Di Rocco C, Guzzetta F

机构信息

Child Neuropsychiatry, Catholic University, Rome, Italy.

出版信息

Childs Nerv Syst. 2006 Aug;22(8):744-59. doi: 10.1007/s00381-006-0151-2. Epub 2006 Jul 12.

DOI:10.1007/s00381-006-0151-2
PMID:16835686
Abstract

INTRODUCTION

Although the neurocognitive assessment in children as in the adults is an important step before and after surgery, in the literature, the data about pre- and postoperative neurocognitive evaluations in children are very few.

OBJECTIVE

The purpose of this paper is to consider some peculiar aspects of the neurocognitive assessment during development, and report literature data about neuropsychological outcome of epileptic children treated with focal resection and hemispherectomy.

RESULTS AND DISCUSSION

The second section concerns our personal experience about a cohort of 45 children with refractory epilepsy operated on before 7 years. The results suggest that early surgical treatment is generally effective for seizure control and behavior improvement in children with refractory epilepsy. Concerning cognitive outcome, we found that the neurocognitive level was unchanged in the majority of the patients.

CONCLUSION

We underline the importance of multicentric studies with standardized neuropsychological assessments in large series of young children.

摘要

引言

尽管儿童和成人的神经认知评估都是手术前后的重要步骤,但在文献中,关于儿童术前和术后神经认知评估的数据非常少。

目的

本文旨在探讨发育过程中神经认知评估的一些特殊方面,并报告有关接受局灶性切除和大脑半球切除术治疗的癫痫儿童神经心理学结果的文献数据。

结果与讨论

第二部分涉及我们对45例7岁前接受手术的难治性癫痫患儿的个人经验。结果表明,早期手术治疗通常对难治性癫痫患儿的癫痫控制和行为改善有效。关于认知结果,我们发现大多数患者的神经认知水平没有变化。

结论

我们强调在大量幼儿中进行标准化神经心理学评估的多中心研究的重要性。

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本文引用的文献

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THE EFFECTS OF HEMISPHERECTOMY ON INTELLECTUAL FUNCTIONING IN CASES OF INFANTILE HEMIPLEGIA.大脑半球切除术对小儿偏瘫患者智力功能的影响
J Neurol Neurosurg Psychiatry. 1961 Aug;24(3):240-9. doi: 10.1136/jnnp.24.3.240.
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fMRI shows atypical language lateralization in pediatric epilepsy patients.功能磁共振成像显示小儿癫痫患者存在非典型语言侧化。
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Greater functional recovery after temporal lobe epilepsy surgery in children.儿童颞叶癫痫手术后功能恢复更佳。
Cochrane Database Syst Rev. 2019 Jun 25;6(6):CD010541. doi: 10.1002/14651858.CD010541.pub3.
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Long term neurocognitive improvement after "late" right hemispherectomy: case report and review of the literature.“晚期”右侧大脑半球切除术后的长期神经认知改善:病例报告及文献综述
Childs Nerv Syst. 2018 Aug;34(8):1599-1603. doi: 10.1007/s00381-018-3775-0. Epub 2018 Mar 21.
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Five-Year Long-Term Prognosis of Epileptic Children After Hemispheric Surgery: A Systematic Review and Meta-analysis.半球手术后癫痫儿童的五年长期预后:一项系统评价和荟萃分析。
Medicine (Baltimore). 2016 Jun;95(23):e3743. doi: 10.1097/MD.0000000000003743.
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Hemispherectomy in the treatment of seizures: a review.大脑半球切除术治疗癫痫:综述。
Transl Pediatr. 2014 Jul;3(3):208-17. doi: 10.3978/j.issn.2224-4336.2014.04.01.
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Cerebral Reorganization after Hemispherectomy: A DTI Study.大脑半球切除术后的脑重组:一项扩散张量成像研究
AJNR Am J Neuroradiol. 2016 May;37(5):924-31. doi: 10.3174/ajnr.A4647. Epub 2016 Jan 14.
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Surgery for posterior quadrantic cortical dysplasia. A review.后象限皮质发育异常的手术治疗。综述。
Childs Nerv Syst. 2014 Nov;30(11):1859-68. doi: 10.1007/s00381-014-2449-9. Epub 2014 Oct 9.
9
Fifty consecutive hemispherectomies: outcomes, evolution of technique, complications, and lessons learned.连续 50 例半脑切除术:结果、技术演变、并发症及经验教训。
Neurosurgery. 2014 Feb;74(2):182-94; discussion 195. doi: 10.1227/NEU.0000000000000241.
10
fMRI and DTI assessment of patients undergoing radical epilepsy surgery.功能磁共振成像和弥散张量成像评估接受根治性癫痫手术的患者。
Epilepsy Res. 2013 May;104(3):253-63. doi: 10.1016/j.eplepsyres.2012.10.015. Epub 2013 Jan 20.
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4
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Neuropsychological outcome following focal cortical removal for intractable epilepsy in children.
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