Andersen M, Wille-Jørgensen P
Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, University of Copenhagen, Denmark.
Eur J Surg. 1991 Sep;157(9):527-30.
Forty-one patients who had all participated in studies about prophylaxis of postoperative deep venous thrombosis (DVT) were investigated 5-8 years after operation. Twenty-five had had asymptomatic DVT detected by 125I-fibrinogen uptake test or 99mTc plasmin scintigraphy and verified by phlebography, four of which were bilateral. They received anticoagulant treatment for three months. Sixteen patients had normal screening tests. At the follow up legs in which DVT had previously been diagnosed were compared with normal legs in patients who did not have DVT. There was no significant difference in subjective symptoms between the two groups of legs, although there were more complaints of oedema and restlessness in legs in which DVT had been diagnosed and varicose veins were more common. When the incidence of varicose veins before the operation and at the follow up was compared, more patients who had had a DVT had developed varicose veins. Blood volume and venous refilling time were measured by strain gauge plethysmography, and were significantly lower in those with a history of DVT than in normal legs. The results indicate impaired venous function in patients who previously had had asymptomatic DVT treated with anticoagulants.
对41名曾参与术后深静脉血栓形成（DVT）预防研究的患者在术后5至8年进行了调查。25名患者通过125I - 纤维蛋白原摄取试验或99mTc纤溶酶闪烁显像检测到无症状DVT，并经静脉造影证实，其中4例为双侧。他们接受了三个月的抗凝治疗。16名患者的筛查试验结果正常。在随访中，将先前诊断为DVT的腿部与未发生DVT患者的正常腿部进行了比较。两组腿部的主观症状没有显著差异，尽管在诊断为DVT的腿部中，水肿和腿部不安的主诉更多，且静脉曲张更常见。当比较手术前和随访时静脉曲张的发生率时，发生过DVT的患者中有更多人出现了静脉曲张。通过应变计体积描记法测量血容量和静脉充盈时间，有DVT病史的患者明显低于正常腿部。结果表明，曾接受抗凝治疗的无症状DVT患者存在静脉功能受损。
