Törnqvist A, Forsgren A, Fäldt K, Jiborn H, Zederfeldt B
Department of Surgery and Experimental Research, University of Lund, Malmö General Hospital, Sweden.
Eur J Surg. 1991 Sep;157(9):539-42.
To quantify the inflammatory reaction to obstruction, alkaline phosphatase and myeloperoxidase activities were measured in specimens of colonic wall from 60 rats. Twenty rats had undergone laparotomy and band obstruction, 20 laparotomy without obstruction and 20 had no operation. The mean activities of both enzymes were increased proximal but not distal to the obstruction, that of alkaline phosphatase significantly so. Despite increase in the number of bacteria, both proximal and distal to the obstruction, no signs of bacterial invasion of the bowel wall were seen either on histological examination or culture. These findings indicate that mechanical factors may be more important than bacteria in causing the increased inflammatory reaction in bowel wall proximal to an obstruction.
为了量化对梗阻的炎症反应，对60只大鼠结肠壁标本中的碱性磷酸酶和髓过氧化物酶活性进行了测量。20只大鼠接受了剖腹术和肠带梗阻，20只进行了无梗阻的剖腹术，20只未接受手术。两种酶的平均活性在梗阻近端升高，但在远端未升高，碱性磷酸酶的活性升高显著。尽管梗阻近端和远端的细菌数量都增加了，但在组织学检查或培养中均未发现肠壁细菌入侵的迹象。这些发现表明，在导致梗阻近端肠壁炎症反应增加方面，机械因素可能比细菌更重要。
