Stoianov Kh, Gŭlŭbova M, Tsaneva M, Velev V
Khirurgiia (Sofiia). 1994;47(2):11-4.
We have studied the Liver and colon of 23 patients histologically, and 15-electron microscopically. In the course of light microscopic observation of the colon wall above the obstruction we found: degeneration and desquamation of epithelial lining, decrease of goblet cells, increase of acid glycoproteins, hypertrophy of myofibrils in the muscle layer and fibrogenesis in the interstitial tissue in between. In liver: there was slight to moderate fibrosis in portal tracts and somewhere in the sinusoids, and moderate inflammatory infiltrate in them. Electron microscopic observations showed: a. in colon above the carcinomatous obstruction we found hypertrophy of muscle cells and in between collagenoblasts I-II type; b. in liver without metastases the space of Disse was distended, with bundles of collagen somewhere. Ito cells showed signs of fibroblast transformation. Our hypothesis is that these chronic changes are a reaction to the protracted obstruction and to colon carcinoma.
我们对23例患者的肝脏和结肠进行了组织学研究，并对其中15例进行了电子显微镜检查。在对梗阻上方结肠壁进行光学显微镜观察的过程中，我们发现：上皮衬里变性和脱落、杯状细胞减少、酸性糖蛋白增加、肌层肌原纤维肥大以及其间间质组织纤维化。在肝脏中：门静脉区和某些肝血窦存在轻度至中度纤维化，并有中度炎症浸润。电子显微镜观察显示：a. 在癌性梗阻上方的结肠中，我们发现肌肉细胞肥大，其间有成纤维细胞I-II型；b. 在无转移的肝脏中，狄氏间隙扩张，有多处胶原束。贮脂细胞显示出成纤维细胞转化的迹象。我们的假设是，这些慢性变化是对长期梗阻和结肠癌的一种反应。
