Newton P, White N
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Annu Rev Med. 1999;50:179-92. doi: 10.1146/annurev.med.50.1.179.
Malaria still kills some 0.5-2.5 million people per year in the tropics. Resistance to the cheap, most commonly used antimalarials continues to spread alarmingly and could outpace drug development. The artemisinin derivatives have had an important clinical impact both on the treatment of resistant falciparum malaria and on the incidence of disease in low-transmission areas. A few promising new antimalarials are being tested clinically but there is an imperative need for cheap, well-tolerated drugs that can be used in short courses, and for strategies to delay the onset of drug resistance. Bed nets have been shown to reduce the incidence of severe malaria in many areas but an effective vaccine is urgently needed.
在热带地区，疟疾每年仍导致约50万至250万人死亡。对廉价且最常用抗疟药物的耐药性仍在以惊人的速度蔓延，其速度可能超过药物研发的速度。青蒿素衍生物在治疗耐药恶性疟疾以及降低低传播地区的疾病发病率方面都产生了重要的临床影响。几种有前景的新型抗疟药物正在进行临床试验，但迫切需要廉价、耐受性良好且可短疗程使用的药物，以及延缓耐药性出现的策略。蚊帐已被证明能在许多地区降低重症疟疾的发病率，但迫切需要一种有效的疫苗。
