Nørgård Bente, Nørgaard Mette, Czeizel Andrew E, Puhó Erzsébet, Sørensen Henrik T
Department of Clinical Epidemiology, Aarhus University Hospital, Denmark.
Dev Med Child Neurol. 2006 Aug;48(8):674-6. doi: 10.1017/S0012162206001411.
According to previous case reports, some congenital abnormalities (CAs) of the brain, such as microcephaly, are a result of intrauterine herpes simplex virus infection. A population-based case-control study was conducted to determine the risk of neural tube defects (NTDs) after maternal herpes labialis infection during pregnancy. Data were taken from the Hungarian Case-Control Surveillance of Congenital Abnormalities from 1980 to 1996, which included 1202 children with NTDs and 21641 comparison children with CAs other than NTDs. The adjusted relative risks (odds ratio [OR]) for NTDs associated with maternal herpes labialis in the first trimester of pregnancy was OR 1.19 (95% confidence interval [CI] 0.68-2.06), and in the entire pregnancy was OR 0.94 (95% CI 0.61-1.44). Self-reported maternal herpes labialis during pregnancy was not associated with a substantially increased risk of NTDs in infants.
根据先前的病例报告，一些脑部先天性异常（CA），如小头畸形，是宫内单纯疱疹病毒感染的结果。开展了一项基于人群的病例对照研究，以确定孕期母体唇疱疹感染后神经管缺陷（NTD）的风险。数据取自1980年至1996年匈牙利先天性异常病例对照监测，其中包括1202名患有NTD的儿童和21641名患有除NTD之外其他CA的对照儿童。孕期头三个月母体唇疱疹相关NTD的调整后相对风险（比值比[OR]）为OR 1.19（95%置信区间[CI] 0.68 - 2.06），整个孕期为OR 0.94（95% CI 0.61 - 1.44）。孕期自我报告的母体唇疱疹与婴儿NTD风险大幅增加无关。
