Nørgård Bente, Puho Erzsebet, Pedersen Lars, Czeizel Andrew E, Sørensen Henrik T
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Am J Gastroenterol. 2003 Sep;98(9):2006-10. doi: 10.1111/j.1572-0241.2003.07578.x.
It has recently been suggested that maternal ulcerative colitis is associated with an almost 4-fold increased risk of congenital abnormalities in offspring. We therefore examined the risk of congenital abnormalities in children born to women with ulcerative colitis.
This was a case-control study within the Hungarian Case Control Surveillance of Congenital Abnormalities, 1980-1996, based on 22,843 newborn children or fetuses with congenital abnormalities and 38,151 children without any detected congenital abnormalities (the control group).
Seventy-one pregnant women (0.3%) had ulcerative colitis in the case group and 95 (0.2%) in the control group. The adjusted overall risk for having a child with congenital abnormalities in women with ulcerative colitis was OR = 1.3 (95% CI = 0.9-1.8). The risk of limb deficiencies, obstructive urinary congenital abnormalities, and multiple congenital abnormalities was OR = 6.2 (95% CI = 2.9-13.1), OR = 3.3 (95% CI = 1.1-9.5), and OR = 2.6 (95% CI = 1.3-5.4), respectively. No association was found for cleft lip with or without cleft palate or cardiovascular defects.
We found no significantly increased overall risk of congenital abnormalities in children born to women with ulcerative colitis. However, our results indicate an increased risk of some selected congenital abnormalities (limb deficiencies, obstructive urinary congenital abnormalities, and multiple congenital abnormalities). More data are needed to determine whether the association between maternal ulcerative colitis and an increased risk of certain congenital abnormalities is causal or is influenced by bias.
最近有研究表明，母亲患溃疡性结肠炎会使后代患先天性异常的风险增加近4倍。因此，我们研究了溃疡性结肠炎女性所生孩子患先天性异常的风险。
这是一项基于1980 - 1996年匈牙利先天性异常病例对照监测的病例对照研究，研究对象包括22843名患有先天性异常的新生儿或胎儿以及38151名未检测到任何先天性异常的儿童（对照组）。
病例组中有71名孕妇（0.3%）患有溃疡性结肠炎，对照组中有95名（0.2%）。溃疡性结肠炎女性生育患有先天性异常孩子的校正总体风险为OR = 1.3（95%可信区间 = 0.9 - 1.8）。肢体缺陷、先天性泌尿系统梗阻性异常以及多发性先天性异常的风险分别为OR = 6.2（95%可信区间 = 2.9 - 13.1）、OR = 3.3（95%可信区间 = 1.1 - 9.5）和OR = 2.6（95%可信区间 = 1.3 - 5.4）。未发现唇裂伴或不伴腭裂以及心血管缺陷与溃疡性结肠炎有相关性。
我们发现溃疡性结肠炎女性所生孩子患先天性异常的总体风险没有显著增加。然而，我们的结果表明某些特定先天性异常（肢体缺陷、先天性泌尿系统梗阻性异常以及多发性先天性异常）的风险有所增加。需要更多数据来确定母亲患溃疡性结肠炎与某些先天性异常风险增加之间的关联是因果关系还是受偏倚影响。
