Robotham J V, Jenkins D R, Medley G F
Department of Biological Sciences, University of Warwick, Coventry, UK.
Epidemiol Infect. 2007 Feb;135(2):328-42. doi: 10.1017/S095026880600687X. Epub 2006 Jul 13.
With reports of hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) continuing to increase and therapeutic options decrease, infection control methods are of increasing importance. Here we investigate the relationship between surveillance and infection control. Surveillance plays two roles with respect to control: it allows detection of infected/colonized individuals necessary for their removal from the general population, and it allows quantification of control success. We develop a stochastic model of MRSA transmission dynamics exploring the effects of two screening strategies in an epidemic setting: random and on admission. We consider both hospital and community populations and include control and surveillance in a single framework. Random screening was more efficient at hospital surveillance and allowed nosocomial control, which also prevented epidemic behaviour in the community. Therefore, random screening was the more effective control strategy for both the hospital and community populations in this setting. Surveillance strategies have significant impact on both ascertainment of infection prevalence and its control.
随着医院获得性耐甲氧西林金黄色葡萄球菌（MRSA）的报告持续增加且治疗选择减少，感染控制方法变得越来越重要。在此，我们研究监测与感染控制之间的关系。监测在控制方面发挥着两个作用：它能够检测出将感染/定植个体从普通人群中移除所必需的个体，并且能够对控制成效进行量化。我们建立了一个MRSA传播动力学的随机模型，探讨在疫情环境下两种筛查策略的效果：随机筛查和入院时筛查。我们同时考虑医院和社区人群，并将控制和监测纳入一个单一框架。随机筛查在医院监测中更有效，并且能够实现医院内控制，这也能防止社区内的流行行为。因此，在这种情况下，随机筛查对医院和社区人群而言都是更有效的控制策略。监测策略对感染患病率的确定及其控制都有重大影响。
