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肝细胞生长因子：对抗肾纤维化的新武器？

Hepatocyte growth factor: new arsenal in the fights against renal fibrosis?

作者信息

Liu Y, Yang J

机构信息

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

出版信息

Kidney Int. 2006 Jul;70(2):238-40. doi: 10.1038/sj.ki.5001661.

DOI:10.1038/sj.ki.5001661
PMID:16838037
Abstract

Hepatocyte growth factor (HGF) has emerged as a potent, endogenous antifibrotic factor that shows an impressive efficacy in ameliorating tissue fibrosis in a wide variety of animal models. Herrero-Fresneda et al. provide new evidence demonstrating that intramuscular injection of HGF gene reduces mortality, inflammation, and renal fibrosis in chronic allograft nephropathy.

摘要

肝细胞生长因子（HGF）已成为一种强效的内源性抗纤维化因子，在多种动物模型中，它在改善组织纤维化方面显示出令人瞩目的功效。埃雷罗 - 弗雷斯内达等人提供了新的证据，证明肌肉注射HGF基因可降低慢性移植肾肾病的死亡率、炎症和肾纤维化。

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Hepatocyte growth factor: new arsenal in the fights against renal fibrosis?肝细胞生长因子：对抗肾纤维化的新武器？
Kidney Int. 2006 Jul;70(2):238-40. doi: 10.1038/sj.ki.5001661.
2
HGF gene therapy attenuates renal allograft scarring by preventing the profibrotic inflammatory-induced mechanisms.肝细胞生长因子基因疗法通过预防促纤维化炎症诱导机制减轻肾移植瘢痕形成。
Kidney Int. 2006 Jul;70(2):265-74. doi: 10.1038/sj.ki.5001510. Epub 2006 May 17.
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HGF as a renotrophic and anti-fibrotic regulator in chronic renal disease.肝细胞生长因子作为慢性肾病中的一种肾营养和抗纤维化调节剂。
Front Biosci. 2008 May 1;13:7072-86. doi: 10.2741/3211.
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Systemic administration of naked plasmid encoding hepatocyte growth factor ameliorates chronic renal fibrosis in mice.全身性给予编码肝细胞生长因子的裸质粒可改善小鼠的慢性肾纤维化。
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Hepatocyte growth factor ameliorates renal interstitial inflammation in rat remnant kidney by modulating tubular expression of macrophage chemoattractant protein-1 and RANTES.肝细胞生长因子通过调节巨噬细胞趋化蛋白-1和调节激活正常T细胞表达和分泌因子的肾小管表达来改善大鼠残余肾的肾间质炎症。
J Am Soc Nephrol. 2004 Nov;15(11):2868-81. doi: 10.1097/01.ASN.0000141962.44300.3A.
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Plasmid pUDK-HGF encoding human hepatocyte growth factor gene attenuates gentamicin-induced kidney injury in rats.编码人肝细胞生长因子基因的质粒pUDK-HGF可减轻庆大霉素诱导的大鼠肾损伤。
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Expression of hypoxia-inducible factor-1α and hepatocyte growth factor in development of fibrosis in the transplanted kidney.缺氧诱导因子-1α和肝细胞生长因子在移植肾纤维化发展中的表达
Transpl Int. 2015 Feb;28(2):180-90. doi: 10.1111/tri.12475. Epub 2014 Oct 27.
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Hepatocyte growth factor gene therapy retards the progression of chronic obstructive nephropathy.肝细胞生长因子基因疗法可延缓慢性阻塞性肾病的进展。
Kidney Int. 2002 Oct;62(4):1238-48. doi: 10.1111/j.1523-1755.2002.kid579.x.
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Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy.肝细胞生长因子在梗阻性肾病小鼠模型中抑制间质纤维化。
Kidney Int. 2001 Apr;59(4):1304-14. doi: 10.1046/j.1523-1755.2001.0590041304.x.
10
Chronic deteriorating renal function and renal fibrosis.
Contrib Nephrol. 2008;159:109-121. doi: 10.1159/000125668.

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