Riekkinen P, Sirviö J, Valjakka A, Riekkinen M, Lammintausta R, Riekkinen P
Department of Neurology, University of Kuopio, Finland.
Brain Res Bull. 1991 Aug;27(2):231-5. doi: 10.1016/0361-9230(91)90073-s.
In the present study the effect of combined anticholinesterase [tetrahydroaminoacridine (THA)] and alpha2-antagonist (antipamezole) treatment were evaluated on nucleus basalis (NB, quisqualic acid) lesion-induced EEG activity changes. THA (1, 3 and 6 mg/kg; an anticholinesterase) and atipamezole (Ati: 3 and 10 mg/kg; an alpha2-antagonist) suppressed dose-dependently NB lesion-induced high-voltage spindle activity and increase in slow/fast activity ratio. A combination of THA (3 mg/kg) and Ati (3 or 10 mg/kg) more effectively suppressed NB lesion-induced HVS activity than either of the drugs alone did. The present results suggest that alpha2-noradrenergic and NB cholinergic systems interact in the regulation of slow wave and HVS activity and that combined stimulation of these systems more effectively stabilize NB lesion-induced EEG changes.
在本研究中，评估了联合使用抗胆碱酯酶药物[四氢氨基吖啶（THA）]和α2拮抗剂（阿替哌唑）治疗对基底核（NB，quisqualic酸）损伤诱导的脑电图活动变化的影响。THA（1、3和6mg/kg；一种抗胆碱酯酶）和阿替哌唑（Ati：3和10mg/kg；一种α2拮抗剂）剂量依赖性地抑制了NB损伤诱导的高压纺锤波活动以及慢/快活动比值的增加。THA（3mg/kg）和Ati（3或10mg/kg）联合使用比单独使用任何一种药物更有效地抑制了NB损伤诱导的HVS活动。目前的结果表明，α2-去甲肾上腺素能系统和NB胆碱能系统在慢波和HVS活动的调节中相互作用，并且联合刺激这些系统能更有效地稳定NB损伤诱导的脑电图变化。
