Riekkinen P, Riekkinen M, Jäkälä P, Sirvioö J, Lammintausta R, Riekkinen P
Department of Neurology, University of Kuopio, Finland.
Brain Res Bull. 1991 Aug;27(2):237-9. doi: 10.1016/0361-9230(91)90074-t.
The present study evaluated the effects of combined alpha2-antagonist (atipamezole) and anticholinesterase (tetrahydroaminoacridine, THA) or muscarinic agonist (pilocarpine) treatments on the high voltage spindle (HVS) activity in aged rats. On their own, high doses of THA (3 mg/kg), pilocarpine (3 mg/kg) and atipamezole (3 mg/kg) suppressed HVS activity. Low doses of THA (1 mg/kg), pilocarpine (1 mg/kg) and atipamezole (1 mg/kg) did not suppress HVS activity. Combinations of low doses of atipamezole and THA or pilocarpine suppressed HVS activity. Our results suggest that 1) the administration of alpha2-antagonist blocked the age-related deficit of thalamocortical activation, 2) a combination of alpha2-antagonist and a cholinergic drug may more effectively stabilize age-related HVS activity than either of the treatments alone.
本研究评估了联合使用α2拮抗剂（阿替美唑）和抗胆碱酯酶药物（他克林，THA）或毒蕈碱激动剂（毛果芸香碱）治疗对老年大鼠高压纺锤波（HVS）活动的影响。单独使用时，高剂量的THA（3毫克/千克）、毛果芸香碱（3毫克/千克）和阿替美唑（3毫克/千克）会抑制HVS活动。低剂量的THA（1毫克/千克）、毛果芸香碱（1毫克/千克）和阿替美唑（1毫克/千克）不会抑制HVS活动。低剂量的阿替美唑与THA或毛果芸香碱联合使用会抑制HVS活动。我们的结果表明：1）给予α2拮抗剂可阻断与年龄相关的丘脑皮质激活缺陷；2）α2拮抗剂与胆碱能药物联合使用可能比单独使用任何一种治疗方法更有效地稳定与年龄相关的HVS活动。
