细胞色素P450环氧合酶CYP2J2与冠状动脉疾病风险
Cytochrome P450 epoxygenase CYP2J2 and the risk of coronary artery disease.
作者信息
Spiecker Martin, Liao Jamesk
机构信息
Department of Medicine II, St. Josef-Hospital Bochum, Gudrunstrasse 56, 44791 Bochum, Germany.
出版信息
Trends Cardiovasc Med. 2006 Aug;16(6):204-8. doi: 10.1016/j.tcm.2006.04.001.
Cytochrome P450 (CYP) enzyme 2J2, an epoxygenase predominantly expressed in the heart, metabolizes arachidonic acid to biologically active eicosanoids. One of the CYP2J2 products, 11,12-epoxyeicosatrienoic acid, has several vasoprotective effects. A frequent promoter polymorphism of CYP2J2 decreases gene expression and is associated with coronary artery disease. This association supports the vascular protective role of CYP-derived eicosanoids in cardiovascular disease.
细胞色素P450（CYP）酶2J2是一种主要在心脏中表达的环氧化酶，可将花生四烯酸代谢为具有生物活性的类二十烷酸。CYP2J2的产物之一11,12-环氧二十碳三烯酸具有多种血管保护作用。CYP2J2常见的启动子多态性会降低基因表达，并与冠状动脉疾病相关。这种关联支持了CYP衍生的类二十烷酸在心血管疾病中的血管保护作用。
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