Hoffman R S, Wipfler M G, Maddaloni M A, Weisman R S
New York City Poison Control Center, NY 10016.
N Y State J Med. 1991 Oct;91(10):436-9.
A retrospective analysis of sedative-hypnotic overdoses reported to the New York City Poison Control Center (NYCPCC) for the years 1988 and 1989 was performed to evaluate the effects of the triplicate benzodiazepine (BZ) prescription program on the incidence and severity of sedative hypnotic overdoses. Although total BZ overdoses fell slightly, from 1,294 in 1988 to 1,265 in 1989, a statistically significant increase in non-benzodiazepine (NBZ) sedative-hypnotic overdoses, from 111 in 1988 to 144 in 1989, was noted. No difference in clinical outcomes between the two years could be demonstrated. These results suggest that the restriction of BZ failed to reduce the incidence or severity of sedative-hypnotic overdose, largely because of the substitution of similar nonrestricted agents.
对1988年和1989年向纽约市中毒控制中心（NYCPCC）报告的镇静催眠药过量使用情况进行了回顾性分析，以评估三联苯二氮䓬（BZ）处方计划对镇静催眠药过量使用的发生率和严重程度的影响。尽管BZ总过量使用量略有下降，从1988年的1294例降至1989年的1265例，但非苯二氮䓬（NBZ）镇静催眠药过量使用量出现了统计学上的显著增加，从1988年的111例增至1989年的144例。两年间的临床结果没有差异。这些结果表明，对BZ的限制未能降低镇静催眠药过量使用的发生率或严重程度，主要是因为类似的非限制药物的替代。
