Nguyen J M, Allain H, Martinet J P, Beneton C, Reymann J M, Decombe R
Centre Régional de Pharmacovigilance, Hôpital Pontchaillou, Rennes.
Ann Med Interne (Paris). 1991;142(3):163-7.
A pharmacoepidemiological survey was carried out in a rural region of France (Brittany) with the help of 54 general practitioners, all of whom belong to a clinical research group. The aim of the survey was 3-fold: to determine the frequency (incidence and prevalence) of anxiolytic and hypnotic drug prescriptions, the sociological characteristics of these drug consumers, and the indications and reasons for prescribing this class of drugs. The population of hypnotic drug and sedative consumers was strikingly dominated by women, 60 years old and over, retired or without a profession. Prescription analysis revealed that these drugs were essentially benzodiazepines whose prevalence and incidence were 17 and 1.76%, respectively. A high frequency of prescription renewals (78%) and an elevated percentage of long-term treatments (more than 9 years) were also noted. Insomnia and dependence are the two main "risk factors" for drug treatments lasting more than one year.
在法国一个农村地区（布列塔尼），借助54名全科医生开展了一项药物流行病学调查，这些医生均属于一个临床研究小组。该调查有三个目的：确定抗焦虑和催眠药物处方的频率（发病率和患病率）、这些药物消费者的社会学特征，以及开具这类药物的适应症和原因。催眠药物和镇静剂消费者群体中，60岁及以上、退休或无业的女性占主导地位。处方分析显示，这些药物主要是苯二氮䓬类药物，其患病率和发病率分别为17%和1.76%。还注意到处方续签频率很高（78%）以及长期治疗（超过9年）的比例很高。失眠和药物依赖是持续一年以上药物治疗的两个主要“风险因素”。
