Ji Jie, Liu Hui-lin, Cheng Jin-lian
Department of Acupuncture and Moxibustion, Beijing Hospital of TCM Affiliated to Capital University of Medical Sciences.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Jun;26(6):500-3.
To observe the effect of "Three ways" method of acupuncture on serum levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in patients with acute ischemic cerebrovascular diseases (ICVD).
Sixty patients with acute cerebral infarction were randomly divided into the treated group treated by "Three ways" method of acupuncture and the control group by hand and foot acupuncture on acupoints of the hands and feet. Serum levels of TNF-alpha and IL-1beta were detected with radioimmunoassay before treatment and at the 6th, 12th and 28th days of treatment. Neurological deficit score (NDS) and Barthel Index (BI) were also observed in the same time.
After treatment, serum levels of TNF-alpha and IL-1beta in both groups decreased significantly (P < 0.05), approaching the normal range at the 28th day of treatment, which were even lower in the treated group than those in the control group, and the decreasing trend were significantly different (P < 0.05). Compared with the control group, the effect in decreasing NDS and increasing BI in the treated group was better than that in the control group (P < 0.05).
"Three ways" method of acupuncture could reduce serum levels of TNF-alpha and IL-1beta, alleviate injury of nervous function so as to improve the daily life ability, superior to hand and foot acupuncture.
观察针刺“三通法”对急性缺血性脑血管病（ICVD）患者血清肿瘤坏死因子-α（TNF-α）和白细胞介素-1β（IL-1β）水平的影响。
将60例急性脑梗死患者随机分为针刺“三通法”治疗组和手足部穴位手足针对照组。于治疗前及治疗第6、12、28天采用放射免疫法检测血清TNF-α和IL-1β水平。同时观察神经功能缺损评分（NDS）和Barthel指数（BI）。
治疗后，两组血清TNF-α和IL-1β水平均显著降低（P < 0.05），治疗第28天时接近正常范围，且治疗组低于对照组，下降趋势有显著差异（P < 0.05）。与对照组相比，治疗组降低NDS和提高BI的效果优于对照组（P < 0.05）。
针刺“三通法”可降低血清TNF-α和IL-1β水平，减轻神经功能损伤，从而提高日常生活能力，优于手足针。
