Fujiwara R T, Geiger S M, Bethony J, Mendez S
Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, DC, USA.
Parasite Immunol. 2006 Jul;28(7):285-93. doi: 10.1111/j.1365-3024.2006.00821.x.
Hookworm infection is a major cause of disease burden for animals and humans. Over the past years, the use of animal models in hookworm infections has been driven by the search of new anthelminthic therapies and, especially, vaccine development. These studies also contributed to the advance of knowledge on immunity to hookworms, offering new insights to understand the nature of this parasitic infection. In this article, we will summarize the essential features of the immune response in the two major animal models of hookworm infections (dog and hamster) and then consider its implication for the human immune response.
钩虫感染是动物和人类疾病负担的主要原因。在过去几年中，钩虫感染动物模型的使用主要是为了寻找新的驱虫疗法，尤其是疫苗开发。这些研究也推动了对钩虫免疫认识的进步，为理解这种寄生虫感染的本质提供了新的见解。在本文中，我们将总结钩虫感染的两种主要动物模型（狗和仓鼠）免疫反应的基本特征，然后探讨其对人类免疫反应的意义。
