Bandettini Peter
Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD 20892, USA.
Int J Psychophysiol. 2007 Feb;63(2):138-45. doi: 10.1016/j.ijpsycho.2006.03.016. Epub 2006 Jul 13.
Most brain imaging researchers would agree with the assertion that functional MRI (fMRI) is progressing. Since fMRI began in 1991, the number of people, papers, and abstracts related to fMRI has been increasing; the technology and methodology has shown advances in robustness and sophistication; the physiology of the signal is better understood; and, even though it hasn't yet made significant headway into the clinical setting, applications are widening. Questions that stem from this optimistic and perhaps overly general set of observations include those that ask what the ultimate theoretical and practical limits of fMRI are and how close are we to approaching these limits. In this commentary, I attempt to provide a snapshot of fMRI as it exists at the end of 2005, and to give a clear impression that not only are we progressing by "dotting the i's and crossing the t's" but that fundamental changes in fMRI methodology and processing are being put forth as the field matures.
大多数脑成像研究人员都会认同功能性磁共振成像（fMRI）正在不断发展这一观点。自1991年fMRI诞生以来，与fMRI相关的人员数量、论文数量和摘要数量一直在增加；该技术和方法在稳健性和复杂性方面取得了进展；对信号的生理学有了更好的理解；而且，尽管它尚未在临床环境中取得重大进展，但应用范围正在不断扩大。源于这一系列乐观甚至可能过于笼统的观察结果的问题包括：fMRI的最终理论和实际极限是什么，以及我们距离达到这些极限还有多远。在这篇评论中，我试图描绘出2005年末fMRI的现状，并清晰地表明，我们不仅在“一丝不苟地”取得进展，而且随着该领域的成熟，fMRI方法和处理正在发生根本性的变化。
