渗透刺激后，大鼠神经垂体加压素神经元中VGLUT2表达上调。
VGLUT2 expression is up-regulated in neurohypophysial vasopressin neurons of the rat after osmotic stimulation.
作者信息
Kawasaki Akiko, Shutoh Fumihiro, Nogami Haruo, Hisano Setsuji
机构信息
Laboratory of Neuroendocrinology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan.
出版信息
Neurosci Res. 2006 Sep;56(1):124-7. doi: 10.1016/j.neures.2006.05.008. Epub 2006 Jul 13.
A second vesicular glutamate transporter (VGLUT2) is detected in magnocellular neurons in the rat hypothalamus. The present study revealed what phenotype of neurons express VGLUT2 mRNA by the histological method. We found that most vasopressin (VP) neurons and several oxytocin (OT) neurons express VGLUT2 mRNA. VGLUT2 gene expression in VP and OT neurons is enhanced with osmotic challenges. In the neurohypophysis, VGLUT2-staining in OT terminals was reduced with osmotic stimulation. These results indicate that VGLUT2 is principally expressed in VP neurons and also in some OT neurons and that VGLUT2 in VP and OT neurons is involved in osmotic regulation.
在大鼠下丘脑的大细胞神经元中检测到第二种囊泡谷氨酸转运体（VGLUT2）。本研究通过组织学方法揭示了表达VGLUT2 mRNA的神经元的表型。我们发现大多数加压素（VP）神经元和一些催产素（OT）神经元表达VGLUT2 mRNA。VP和OT神经元中的VGLUT2基因表达随着渗透压挑战而增强。在神经垂体中，OT终末的VGLUT2染色随着渗透压刺激而减少。这些结果表明VGLUT2主要在VP神经元中表达，也在一些OT神经元中表达，并且VP和OT神经元中的VGLUT2参与渗透压调节。
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